On the Decomposition of the Narcotic α-pyrrolidinovalerophenone in Nasway
https://doi.org/10.30764/1819-2785-2020-4-19-26
Abstract
The article provides information on the decomposition of the narcotic α-pyrrolidinovalerophenone (α-PVP) in nasway and the results of the study of the decomposition rate for the drug in an alkaline environment. It is shown that in a week, the content of α-PVP in nasway reduces by almost two times, and in 1,5–2 months, it is not found in the sample. Similar results were acquired for aqueous alkaline solutions of α-PVP.
The information obtained can be useful for experts specializing in “research of narcotics, psychotropic substances and their precursors, potent and poisonous substances” when conducting examinations and research.
About the Authors
L. I. ModinovaRussian Federation
Larisa Ivanovna Modinova – Candidate of Chemistry, Deputy Head of the Department of Forensic Examinations of Materials, Substances, Products; Forensic center of the Main Department of the Ministry of Internal Affairs of the Russian Federation in the Nizhny Novgorod region
Nizhny Novgorod, 603134
O. V. Panteleeva
Russian Federation
Olga Viktorovna Panteleeva – Chief Expert, Department of Forensic Examinations of Materials, Substances, Products; Forensic Center of the Main Department of the Ministry of Internal Affairs of the Russian Federation in the Nizhny Novgorod region
Nizhny Novgorod, 603134
References
1. Zav’yalova A.A., Zav’yalov V.V., Morgunkova Yu.M., Lyubetskii G.V., Semenov S.I. Forensic Analysis of Non-Smoking Tobacco Mixtures. Methodical Recommendation. Moscow: EKTs MVD Rossii, 2014. 32 p. (In Russ.)
2. Raganin M.U., Zätterström U., Lindholm J. Quantitative and Qualitative Chemical Analysis of Smokeless Tobacco Nasvay. Science & Healthcare. 2016. No. 1. P. 106–119. (In Russ.)
3. Shevyrin V.A., Melkozerov V.P. Expert Analysis of Some Pyrovalerone and N-methylephedrone Substances. Information Letter for Expert Divisions. Yekaterinburg: BEKO UFSKN Rossii po Sverdlovskoi oblasti i EKTs GU MVD Rossii po Sverdlovskoi oblasti, 2011. 22 p. (In Russ.)
4. Shima N., Katagi M., Kamata H., Matsuta S., Sasaki K., et al. Metabolism of the Newly Encountered Designer Drug α-pyrrolidinovalerophenone in Humans: Identification and Quantitation of Urinary Metabolites. Forensic Toxicology. 2014. Vol. 32. P. 59–67. https://doi.org/10.1007/s11419-013-0202-9
5. Marinetti L.J., Antonides H.M. Analysis of Synthetic Cathinones Commonly Found in Bath Salts in Human Performance and Postmortem Toxicology: Method Development, Drug Distribution and Interpretation of Results. Journal of Analytical Toxicology. 2013. Vol. 37. No. 3. P. 135–146. https://doi.org/10.1093/jat/bks136
6. Bekhterev V.N., Gavrilova S.N., Koshkareva E.V., Shipanov I.N. The Determination of Pyrovaleron in the Urine. Forensic Medical Expertise. 2017. Vol. 60. No. 3. P. 27–31. (In Russ.). https://doi.org/10.17116/sudmed201760327-31
7. Moskaleva E.V., Eroshchenko N.N., Kiryushin A.N., Kardonsky D.A., Yeganov A.A. The Detection and Identification of Alpha-Pyrrolidino- valerophenone (α-PVP) and Its Metabolites in the Objects of the Forensic Chemical Examination. Forensic Medical Expertise. 2017. Vol. 60. No. 1. P. 19–22. (In Russ.). https://doi.org/10.17116/sudmed201760119-22
8. Negreira N., Erratico C., Kosjek T., van Nuijs A.L.N., Heath E., Neels H., Covac A. In Vitro Phase I and Phase II Metabolism of α-pyrrolidinovalerophenone (α-PVP), Methylenedioxypyrovalerone (MDPV) and Methedrone by Human Liver Microsomes and Human Liver Cytosol // Analytical and Bioanalytical Chemistry. 2015. No. 407. P. 5803–5816. https://doi.org/10.1007/s00216-015-8763-6
9. Sykutera M., Cychowska M., Bloch-Boguslawska E. A Fatal Case of Pentedrone and α-pyrrolidinovalerophenone Poisoning. Journal of Analytical Toxicology. 2015. Vol. 39. No. 4. P. 324–329. http://doi.org/10.1093/jat/bkv011
10. Casale J.F., Hays P.A. The Characterization of α-pyrrolidinopentiophenone. Microgram Journal. 2012. Vol. 9. No. 1. P. 33–38.
11. Tsujikawa K., Kuwayama K., Kanamori T., Iwata Y., Inoue H. Thermal Degradation of α-pyrrolidinopentiophenone During Injection in Gas Chromatography/Mass Spectrometry. Forensic Science International. 2013. Vol. 231. No. 1–3. P. 296–299. https://doi.org/10.1016/j.forsciint.2013.06.006
12. Krasnov K.S. (ed). Physical Chemistry. Book 2. Electrochemistry. Chemical Kinetics and Catalysis. 3rd ed. / Moscow: Vysshaya shkola, 2001. 319 p. (In Russ.)
Supplementary files
Review
For citations:
Modinova L.I., Panteleeva O.V. On the Decomposition of the Narcotic α-pyrrolidinovalerophenone in Nasway. Theory and Practice of Forensic Science. 2020;15(4):19-26. (In Russ.) https://doi.org/10.30764/1819-2785-2020-4-19-26